Rojan G.M. AL-ALLAFF, Enass Waad AL-HADIDI, Hiyam Adil ALTAII
Turkish Journal of Immunology - 2026;14(1):35-44
Objective: This study aimed to determine the concentration of anti-type II collagen (anti-CII) and interleukin-1 beta (IL-1beta) in patients with hyperuricemia and to evaluate their relationship with uric acid and other hematological parameters. Materials and Methods: This case-control study included patients with chronic hyperuricemia and healthy controls. Serum uric acid levels, complete blood counts, and quantitative levels of IL-1beta and anti-CII antibodies were measured using an enzyme-linked immunosorbent assay (ELISA). Results: A total of 80 patients with chronic hyperuricemia and 40 healthy controls were included in the study. Data analysis showed that uric acid (8.20 +/- 1.06 mg/dL vs 4.99 +/- 1.20 mg/dL; p<0.001), MID cells (627.48 +/- 283.84 cells/µL vs 375.29 +/- 173.43 cells/µL; p=0.001), anti-CII (9.67 +/- 7.30 ng/mL vs 5.58 +/- 1.35 ng/mL; p=0.027), and IL-1beta (2.21 +/- 2.18 pg/mL vs 0.94 +/- 0.81 pg/mL; p=0.024) were significantly higher in patients than in controls. Regression analysis revealed a significant negative correlation between MID cells and hemoglobin (Hb) levels (R2=0.30; p=0.049). Notably, IL-1beta was the only variable that showed a statistically significant effect on anti-CII levels (beta=0.578, p=0.014). Conclusion: The study concludes that the anti-CII-mediated autoimmune response in gout occurs through an IL-1beta-mediated production axis rather than as a direct consequence of elevated uric acid levels. Moreover, the negative correlation between MID cells and Hb suggests that chronic gout may exert a systemic suppressive effect on erythropoiesis.
