Sevgi Yumrutepe, Mehmet Erdem, Tuğba Raika Kıran, Feyza İnceoğlu, Asiye Özkan, Süleyman Nogay
Eurasian Journal of Critical Care - 2026;8(1):35-39
Background: We aimed to evaluate the diagnostic value of hemogram-based inflammatory parameters particularly leukocyte, leukocyte-to-platelet ratio and neutrophil-to-platelet ratio in identifying myocardial infarction among patients presenting to the emergency department with chest pain. Methods: A total of 60 myocardial infarction and 60 non-myocardial infarction patients aged over 18 years who presented to the emergency department with chest pain between January and February 2025 were retrospectively analyzed. Hemogram, biochemistry, electrocardiography, and creatine kinase-MB values were evaluated. leukocyte, leukocyte-to-platelet and neutrophil-to-platelet ratios were compared between the two groups. The discriminatory performance of these parameters was assessed using Receiver Operating Characteristic analysis, and optimal cutoff values were determined using the Youden index. Results: Glucose, creatine kinase-MB, leukocyte, neutrophil count, leukocyte-to-platelet ratio, and neutrophil-to-platelet ratio levels were significantly higher in the myocardial infarction group compared with the control group (p<0.001). In Receiver Operating Characteristic analysis, leukocyte-to-platelet ratio demonstrated the highest diagnostic accuracy with an AUC of 0.732. The cutoff value for leukocyte-to-platelet ratio was 0.0365, yielding a sensitivity of 71.7% and specificity of 66.7%. The AUC values for neutrophil-to-platelet ratio and glucose were 0.674 and 0.672, respectively. Conclusion: Rapid, low-cost, and readily accessible parameters such as leukocyte, leukocyte-to-platelet ratio and neutrophil-to-platelet ratio were shown to have significant discriminatory value in diagnosing myocardial infarction. Particularly, the high diagnostic accuracy of leukocyte-to-platelet ratio, supports its potential use as a practical biomarker to assist clinical decision-making while awaiting troponin results.
