ANASTASİYA A KOTLYAROVA, KONSTANTİN YU PONOMAREV, EKATERİNA A MOROZOVA, DİNA V KORCHAGINA, EVGENİY V SUSLOV, ALLA V PAVLOVA, TATYANA G TOLSTIKOVA, KONSTANTİN P VOLCHO, NARİMAN F SALAKHUTDINOV
Journal of Research in Pharmacy - 2020;24(2):196-204
The aim of this work is to study the effect of agents combining fragments of monoterpenoids and 3, 7-diazabicyclo[3.3.1]nonane (bispidine) on the performance of mice. Physical endurance was studied using two tests: exhaustive swimming with a load of 7% of body weight (after single dosing) and exhaustive treadmill running (after single dosing and a 7-day administration). It has been shown for the first time that derivatives of monoterpenoids with 3, 7-diazabicyclo[3.3.1]nonane moiety containing methyl substituents at positions 1 and 5 have a stimulatory effect on the performance of mice, which exceeds the effect of the reference drug bromantane after single dosing. Compound K1-458, which contains ()-myrtenal residues linked to a bispidine fragment via amino groups, is the most effective in increasing the duration of running and swimming at a dose of 100 mg/kg after single intragastric administration. It has been also established that the LD50 for these compounds exceeds 1, 000 mg/kg.
