HARDİ HARDI, YULİA YUSRİNİ DJABIR, HESTY SETIAWATI, SUBEHAN LALLO
Acta Pharmaceutica Sciencia - 2022;60(4):413-422
Diabetes mellitus is associated with abnormalities in lipid metabolism and weight loss. This study aimed to examine breadfruit (Artocarpus altilis (Parkinson) Fosberg) leaf extract"s effects on lipid profiles and weight loss in alloxan-induced diabetic rats. Forty-five male Wistar rats were injected with alloxan and divided into treatment groups: placebo, Artocarpus altilis leaf extract (100, 200, or 400 mg/kg) or insulin (6U/200 g). Five additional rats were included as normal controls. Following 14 days of treatments, Artocarpus altilis extract lowered the blood glucose (BG) level, but only significant at 400 mg/kg dose. Eighty percent of rats in the placebo group had a significant weight loss compared to 40% of rats in the 400 mg/kg group. The placebo group had significantly higher total cholesterol (TC) compared to controls (p<0.05) and the Artocarpus altilis extract treatment significantly reduced the TC level (p<0.05). In conclusion, Artocarpus altilis extract treatment improves BG, lipid metabolism, and weight loss in alloxan-induced diabetic rats.
