Yücel KANAL, Görkem AYHAN, Canan Elif YILDIZ, Mehmet Fatih AYGÜN, Adem ÇELİK, Idris YAKUT, Hatice Eftal Şeyda KANAL, Omaç TÜFEKÇİOĞLU
Haydarpaşa Numune Medical Journal - 2026;66(2):137-141
Introduction: Bendopnea is defined as the onset of dyspnea within 30 s of bending forward and is linked to increased right atrial and post-capillary wedge pressures. Diuretics reduce intravascular volume by inhibiting sodium reabsorption, thereby lowering cardiac filling pressures. This study aimed to evaluate the effects of non-hydrochlorothiazide (HCTZ) diuretics on symptoms and diastolic parameters in obese patients with bendopnea. Methods: This retrospective, single-center study included 120 obese patients presenting with bendopnea to the cardiology outpatient clinic. Group 1 comprised patients who either received no medication or were prescribed only HCTZ. Group 2 included those treated with non-HCTZ diuretics (spironolactone, spironolactone + HCTZ, or indapamide). After 1 month, symptom status and clinical parameters were reassessed. Results: The mean age was 57+/-9.1 years, with 90% female participants. At 1-month follow-up, bendopnea frequency was significantly lower in Group 2 compared to Group 1 (16.1% vs. 96.6%; p<0.001). Improvements were also observed in systolic mean blood pressure, NT-proBNP levels, and E/e ? values in patients in Group 2. Discussion and Conclusion: Non-HCTZ diuretics significantly alleviated bendopnea symptoms and improved diastolic parameters in obese patients. These findings suggest that non-HCTZ diuretics may offer symptomatic and hemodynamic benefits in this population.
