DİLAN ALTINTAŞ URAL, DUYGUN ALTINTAŞ AYKAN, MUHAMMED SEYİTHANOĞLU, ALPER URAL
Comprehensive Medicine - 2024;16(3):191-197
INTRODUCTION: Liver is one of the most affected tissues after abdominopelvic surgery. Many substances were employed to prevent liver damage during surgery. In this study, we aimed to investigate effects of tadalafil, phosphodiesterase-5 (PDE-5) inhibitor, on the liver after intraperitoneal abrasion. METHODS: Thirty rats were induced ileal and cecal abrasion model. Subsequently, group 1: received saline (control), group 2: tadalafil 1 mg/kg, group 3: tadalafil 10 mg/kg, group 4: tadalafil 1 mg/kg for 7 days, group 5: tadalafil 10 mg/kg for 7 days. After treatments, serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) were analyzed by ELISA. Liver tissue samples were analyzed for tissue total oxidant/antioxidant status (TOS, TAS), thiol, TTL (total thiol level), NTL (native thiol level) using colorimetric appropriate methods. Results: We found that serum ICAM-1 in group 5 was higher than other groups, ICAM-1 in group 4 was higher than group 2 (g1 vs. g5 p<0.001, g2 vs. g4 p=0.016, g2 vs. g5 p<0.001, g3 vs. g5 p=0.004, g4 vs. g5 p=0.03). PDGF was higher in group 5 than group 1 (p=0.025). Tissue TTL and NTL were higher in group 5 than in group 1 (p=0.035, p=0.002). TOS was higher in group 5 than groups 1 and 4 (p=0.028, p=0.028). TAS was higher in group 5 than group 3 (p=0.018). DISCUSSION AND CONCLUSION: High-dose and long-term administration of tadalafil increased oxidative and inflammatory responses in liver tissue.
