SHAHROKH KHOSHSIRAT, ALİ ASGHAR PEYVANDI, MAHBOBEH OROEI, HASSAN PEYVANDI, ALİ REZAEIFARD
Turkish Journal of Oncology - 2020;35(1):64-69
OBJECTIVE Multiple potential risk factors have been proposed for the development of thyroid cancer. Type 2 diabetes and ABO blood group had a significant relationship with some cancers. These agents may be related to thyroid cancer. This study investigates the association between thyroid cancer and diabetes and the ABO blood group. METHODS This analytic study was conducted in patients with thyroid cancer (n=87) and the individuals cancerfree (n=929). The odds ratio of thyroid cancer was estimated in diabetic patients after adjusting age and sex. The distribution of the blood groups in both groups was determined and compared with considering confidence interval 95%. RESULTS We observed a significant association between thyroid cancer and type 2 diabetes (odds ratio (OR): 4.42, 95% confidence interval (CI): 2.04-9.57, p<0.001). There was a significantly lower frequency of blood type A in patients with thyroid cancer (25.3%) compared to the control group (34.4%) with a reduced risk of 43% (OR: 0.57; 95% CI: 0.330.97, p=0.04 ). The patients with blood type B had a borderline risk of thyroid cancer (OR: 1.60, 95% CI: 0.962.70, p=0.07). CONCLUSION Our findings show the relationship between type 2 diabetes and thyroid cancer. The blood type A can significantly decrease the risk of thyroid cancer, and the blood type B may increase. To confirm these results, further studies should be conducted.
