MUAZZEZ GARİBAĞAOĞLU, ÜMİT ZEYBEK, SİBEL ERDAMAR, AYDIN ÇEVİK, FUNDA ELMACIOĞLU
Advances in Molecular Medicine - 2007;3(1):35-40
Objectives: To examine histopathological effects of deep-fried sunflower oil on rat livers. Methods: Rats in the experimental group were fed for 5 weeks with deep-fried sunflower oil. Rats in the control group were fed for the same period with fresh sunflower oil. At the end of the study, the bodies and livers of the rats were weighed, and the livers were histopathologically examined. Results: Hepatic parenchymal cells of rats fed with deep-fried sunflower oil showed diffuse hydropic and lipid degeneration, moderate but obvious levels of parenchymal necrosis, dense mononuclear cell infiltration in sinusoids and portal areas, and irregular piecemeal necrosis in the parenchymal borders of portal areas. There was not any histıopathological change in the livers of the control group. Conclusion: We think that sunflower oil used in deep fat frying is toxic to rat liver and, consequently, may be toxic to human liver.
