HATİCE SELEN SÖNMEZ KANAR, MURAT OKLAR, AYSEGUL PENBE, AYSU ARSAN, ENGİN ERSİN ŞİMŞEK
Southern Clinics of Istanbul Eurasia - 2021;32(1):75-79
INTRODUCTION: The aim of our study was to evaluate the anterior and posterior ocular parameters in patients with Graves’ ophthalmopathy (GO) compared to control. METHODS: Sixty-eight patients with GO and 40 healthy controls were included in the study. The patients with GO were divided into two groups according to their clinical activity score (CAS). Patients with ≥3/7 CAS points were entitled as active GO and CAS points less than 3/7 were entitled as inactive GO. Spherical refractive error (SRE), astigmatic refractive error (ARE), central corneal thickness, intraocular pressure, and axial length (AL) were recorded. The subfoveal choroidal thickness (SFCT) and global and sectorial peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured by spectral domain- optical coherence tomography. Results: The patients with active GO had significantly higher myopic SRE and ARE compared to patients with inactive GO and healthy controls (p=0.040 and 0.030, respectively). The mean AL was statistically significant taller in both GO groups than control (p=0.048) but there were no significant differences in AL between the patients with active GO and inactive GO. Patients with active GO and inactive GO had significantly higher SFCT than controls (p≤0.001). Furthermore, patients with active GO had significantly thinner global pRNFLT, superior pRNFLT, inferior pRNFLT, and temporal pRNFLT than patients with inactive GO and active GO. The patients with inactive GO had only thinner inferior pRNFLT compared to healthy controls. DISCUSSION AND CONCLUSION: The patients with GO had significant alterations in refractive status, SFCT, and pRNFLT, especially patients with active GO. These parameters might be potential adjuncts in the evaluation of GO patients and preventing ocular serious complications.
