NAZİFE DOĞAN, ALPER GÜMÜŞ, MESUT AYER
International Journal of Medical Biochemistry - 2025;8(3):185-191
Objectives: Serum protein electrophoresis is a low-cost and low-sensitivity technique used for screening monoclonal gammopathies with capillary protein electrophoresis. Immunofixation electrophoresis, on the other hand, is a highly sensitive technique used in the diagnosis, treatment, and follow-up of monoclonal gammopathies in patients with peak or abnormal patterns in serum protein electrophoresis scans; however, it is also more expensive. In monoclonal gammopathies, excessive production of immunoglobulins, known as monoclonal bands, is observed as sharp bands in immunofixation electrophoresis. In this study, we aimed to highlight the contribution of serum protein electrophoresis and immunofixation electrophoresis in detecting monoclonal bands in laboratory reports and their role in the early diagnosis and follow-up of patients.
