Tolga ÇİFTPINAR, Merve ALDIKAÇTIOĞLU TALMAÇ, Sultan MAYUNCUR, Semra YÜKSEL, İsmail ÖZDEMİR
Comprehensive Medicine - 2026;18(1):67-72
Objective: Preterm premature rupture of membranes (PPROM) is associated with an increased risk of pregnancy complications. This study evaluated the changes in coagulation parameters in pregnant women with this condition. The aim of the study is to investigate how coagulation parameters, particularly clotting time tests such as PT and aPTT, vary in pregnant patients with PPROM, which is among the causes of premature birth. Materials and Methods: This case-control study was retrospectively planned and conducted using data from a tertiary center where maternal-fetal treatment and monitoring were provided. The study participants were divided into three groups: the early PPROM group with complaints of water leakage at 12-24 weeks of gestation, the late PPROM group with complaints of water leakage at 24-37 weeks of gestation, and the control group who did not have any complaints at 12-37 weeks of gestation. The coagulation parameters examined were the activated partial thromboplastin time, prothrombin time, INR, and fibrinogen values. Results: The study comprised 2086 pregnant women, among whom 606 were diagnosed with early PPROM, 609 were diagnosed with late PPROM, and 871 were included in the control group. Notably, significant prolongation was observed in the PT and aPTT values of the early PPROM and late PPROM patients compared to healthy pregnant women. Conclusion: This study highlighted that the PT and aPTT might be prolonged in pregnant women with PPROM. The potential role of coagulation parameters in the pathophysiology of early and late PPROM may be helpful for effective management of these conditions.
