Christopher GEORGE, Gurneer SIDHU, Hridini DAVE, Smira SONTHALIA, Giuliana RAMIREZ, Leah RUPP, Rian WASNIEWSKI, Ashley BURNIDGE, Myka PUNZALAN, Aquib AHMED, Peyton WARREN, Manasa MASKEY, Diya PATEL, Paul NGUYEN
Journal of Updates in Cardiovascular Medicine - 2026;14(1):1-12
Parkinson's disease (PD) is a common neurodegenerative disorder that is becoming increasingly prevalent in the United States. Current research suggests a possible bidirectional relationship between cardiovascular disease (CVD) and PD. This review aims to synthesize relevant evidence to analyze the interplay between CVD and PD. Researchers utilized academic databases to find current and relevant studies that met the defined inclusion and exclusion criteria. After reviewing various articles, a majority of evidence suggests a correlation between CVD and worsening prognosis for PD patients regarding mortality, cardiac dysfunction, and blood pressure. Conflicting and inconclusive studies are acknowledged within this review, showing the complexity of this subject and the need for continuing research to determine causality. Future research should adopt a prospective study design with stricter diagnostic methods and detailed sample demographics to identify confounding variables. The underlying biological and physiological background within these diseases should also be studied to help better understand the interplay between CVD and PD.
