ALİ SIZLAN, TALHA ATALAY, EROL KISMET, BÜLENT ÜNAY, OĞUZHAN YILDIZ, RUŞEN DÜNDARÖZ
Kocatepe Tıp Dergisi - 2003;4(2):13-18
Rapid venous access may be a challenge during emergency, especially in pediatric cases. On the other hand, it has been suggested that high volumes of fluid can be injected into the corpora cavernosa. One of the emergency situations required rapid intravenous (IV) access is status epilepticus (SE). Phenytoin (PHT) is one of the major drugs used in the treatment of SE. As far as we know, there has no investigation comparing IV and intracavernous (IC) loading of PHT. In this study, PHT was administered to rabbits using both IV and IC routes at the dose of 20 mg/kg. Saphenous vein blood samples were drawn at 1, 5, 10, 15, 20, 25, 30 minutes following administration in both the IC group and the IV groups. Serum PHT concentrations were determined and their profiles were compared. Although the blood levels of PHT were found to be statistically significantly lower with IC administration, but it was found to be higher than minimum effective concentration. Our study showed that PTH can be absorbed by the IC route as fast as by the IV route. Research is needed to study this technique in more detail before clinical applications.
