Özge ÖZTÜRK, Seval YILMAZ ERGANİ, Recep Taha AĞAOĞLU, Figen GÜNDAY, Aysu Yeşim TEZCAN, Kadriye Yakut YÜCEL, Zehra Vural YILMAZ
Gulhane Medical Journal - 2026;68(2):102-108
Aims: To date, no studies have examined the relationship between the hemoglobin-albumin-lymphocyte-platelet (HALP) score and the systemic inflammatory response index (SIRI) in pregnancy. The aim of this study was to compare HALP, SIRI, and other systemic inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and aggregate index of systemic inflammation (AISI), between pregnant women with intrahepatic cholestasis of pregnancy (ICP) and healthy pregnant controls. Methods: This retrospective cross-sectional study included pregnant women diagnosed with ICP and healthy controls matched for age and pregnancy. Participants were screened using complete blood count data collected at diagnosis. The primary endpoint was a comparison of systemic inflammatory markers, including NLR, MLR, PLR, SII, SIRI, AISI, and HALP score. Results: A total of 143 pregnant women with a mean age of 29.3 years were included. Of these, 73 were in the ICP group and 70 were in the control group. PLR, SII, and HALP scores were significantly higher in the ICP group than in the control group (p=0.026, p=0.019, and p=0.016, respectively), while NLR, MLR, SIRI, and AISI showed no significant differences between the groups. Weak positive correlations were found between the presence of ICP and each of PLR (r=0.187, p=0.025), SII (r=0.197, p=0.019), and HALP (r=0.201, p=0.016). Receiver operating characteristic analysis showed that HALP [area under the curve (AUC)=0.616, sensitivity 97%, p=0.016], SII (AUC=0.614, specificity 94%, p=0.019), and PLR (AUC=0.608, specificity 89%, p=0.026) had significant predictive value. Conclusions: HALP and selected systemic inflammatory indices can serve as helpful biomarkers for the diagnosis of ICP.
