HATİCE BAŞARAN GÖKŞEN, ALAETTİN ARSLAN
Turkish Journal of Oncology - 2025;40(1):76-82
OBJECTIVE Nowadays, Gustave-Roussy immunoscoring is used to predict treatment sensitivity and survival, especially in the patient group for which immunotherapy is planned for lung cancer. In this study, we aimed to compare the prognostic importance of systemic inflammatory parameters with the immune score in pancreatic cancer (PC), which is a type of cancer with an immunological and poor prognosis. METHODS 101 patients diagnosed with PC who were diagnosed or treated in our center between 2014 and 2024 were included in the study. The values of prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), Gustave Roussy immune score (GRIm-s), and eosinophil-to-monocyte ratio (EMR) were calculated according to laboratory parameters at the time of diagnosis. Survival and regression analyses were performed inter-groups for each variable. RESULTS Cut-off values were calculated for GRIm-s, PNI, NLR, PLR, hemoglobin, albumin, lactate dehydrogenase, and EMR. In terms of survival analyses, GRIm-s, PNI, hemoglobin, NLR, albumin, and PLR were statistically significant for OS (p=0.00, p=0.03, p=0.032, p=0.00, p=0.00, p=0.029). In the multivariate Cox regression analysis, GRIm-s was the most powerful variable affecting OS independently (HR: 2.538, 95% CI: 1.558-4.135, p:0.000). CONCLUSION GRIm-s is a reliable and prognostic value in terms of survival in PC. Besides, the predictive ability of that score is much better than other values.
