Behice HAN ALMIŞ, Gunnur HAKYEMEZ GEYLANİ, Şeyma SEHLİKOĞLU, Elif BALTACI, Oğuzhan TÜZÜN, Özge Selin ÖZEN SEKMEK, Gürkan ÇIKIM
Psychiatry and Behavioral Sciences - 2026;16(2):111-119
Objective: The connection between oxytocin and testosterone levels and impulsivity in Antisocial personality disorder (ASPD) is a subject that has not been thoroughly explored. Thus, the present study aims to investigate the relationship between impulsivity and the levels of oxytocin and testosterone in individuals with ASPD. Methods: The present research examined and compared the levels of impulsivity between healthy controls and patients diagnosed with ASPD, utilizing the Short Form of the Barratt Impulsiveness Scale (BIS-11-SF). Furthermore, blood samples were also drawn from the two groups to analyze and compare the hormone levels of oxytocin and testosterone between them. Then, the association of these hormone levels with impulsivity in both groups was assessed. The total sample involved 73 participants: 37 patients and 36 controls. Results: The findings of our study indicate that all subtypes of impulsivity are elevated in individuals diagnosed with ASPD when compared to healthy controls (p <0.001). Patients with ASPD exhibited significantly reduced levels of oxytocin and testosterone in comparison to healthy controls (p < 0.001 and p = 0.003, respectively). No correlation was observed between BIS-11-SF scores and oxytocin. Conversely, a negative correlation was identified between Barratt 4 and 7 and testosterone levels. Conclusion: Our findings, including the observation of reduced levels of oxytocin and testosterone hormones in individuals diagnosed with APSD when compared to healthy controls, and the identification of a negative correlation between Barratt 4 and 7 and testosterone levels, indicate a negative relationship between impulsivity and testosterone hormone levels in these individuals.
