Memet ASLANYAVRUSU, Gülhan SARIÇAM, Fahrettin EGE
Turkish Journal of Cerebrovascular Diseases - 2026;32(2):92-99
Objective: stress hyperglycemia reflects the neuroendocrine stress response of the body during acute illness, independent of chronic glycemic status. This study aimed to evaluate the association between the stress hyperglycemia ratio (shR) and clinical outcomes in patients with cerebral venous thrombosis (CVT). Methods: a total of 72 adult patients diagnosed with cerebral venous thrombosis (CVT) were retrospectively analyzed. The stress hyperglycemia ratio (shR) was calculated as the ratio of admission plasma glucose to estimated average glucose (ea G). Variables between groups were compared using the chi-square test and Mann-Whitney U test, as appropriate. Receiver operating characteristic (ROC) curve analysis and multivariable binary logistic regression analyses were performed to evaluate the prognostic significance of shR. Results: Of the patients, 61.1% (n=44) were female, and the median age was 38.0 years (IQR: 32.0-47.2). a cute onset and hemorrhagic transformation were significantly more frequent in patients with poor outcomes (p=0.016 and p=0.029, respectively). shR and admission glucose levels were significantly higher in the poor outcome group (p<0.001). ROC analysis demonstrated that shR had a high predictive value for poor outcomes ( aUC: 0.895; 95% CI: 0.810-0.981), with an optimal cut-off value of 1.30, yielding a sensitivity of 95.5% and a specificity of 80.0%. Multivariable logistic regression analyses demonstrated that both shR and admission glucose were independently associated with poor clinical outcomes. Conclusion: This study suggests that the stress hyperglycemia ratio (shR) may be associated with poor clinical outcomes in patients with CVT. These findings indicate that shR could have potential prognostic relevance not only in arterial stroke but also in cerebrovascular diseases of venous origin.
