GOKHAN AKDAĞ, ŞÜKRAN ERTEN, SELÇUK AKAN, GÜNİZ YANIK ÜSTÜNER, ORHAN KÜÇÜKŞAHİN, TURAN HİLMİ YEŞİL, BÜLENT YALÇIN
Annals of Clinical and Analytical Medicine - 2020;11(1):10-14
Aim: In this study, we aimed to reveal the relationship between disease activity level and serum 25 (OH) vitamin D level in rheumatoid arthritis (RA), a chronic autoimmune disease. Material and Method: Ninety-one patients with RA and 90 healthy controls were included in the study. DAS28 score and 25 (OH) vitamin D levels of the patient group and control group were compared. Results: The mean serum 25 (OH) vitamin D level of patients and controls were 16, 8 ± 10, 1 μg / L and 28.3 ± 16 μg / L, respectively. 25 (OH) vitamin D levels were statistically significantly lower in the patients group than in the control group (p <0.001). In total, serum 25 (OH) vitamin D levels and DAS28 scores of the patients were not significantly correlated (r = -0.058, p = 0.588). Correlation analysis according to sexes showed negative correlation between serum 25 (OH) vitamin D level and DAS28 score in males (r = -0, 646, p = 0, 002) and no correlation was found in females (r = 0, 113, p = 0, 346). Discussion: Low serum 25 (OH) vitamin D may play a role in the pathogenesis of RA patients. The significant relationship between disease activity and serum 25 (OH) vitamin D level in male gender shows that this effect is more prominent in male sex.
