Dilek BULDUM, Şefik Eser ÖZYÜREK, Önder AYDIN, Nursen KURTOĞLU
Journal of Health Sciences and Medicine - 2026;9(2):365-369
Aims: This study aimed to investigate the association between multiple HPV DNA positivity and the presence of high-grade cervical intraepithelial lesions or cervical cancer. Methods: The medical records of 164 patients who underwent colposcopic biopsy in the department of obstetrics and gynecology were retrospectively reviewed. PAP smear results (LGSIL, ASCUS, ASC-H), HPV test positivity, and HPV genotypes were evaluated. Based on colposcopic biopsy findings, patients were categorized into two groups: group I: negative, LSIL, koilocytosis, and CIN I; group II: HSIL, CIN II-III, and squamous cell carcinoma. Results: No statistically significant association was found between the presence of multiple HPV genotypes, single HPV genotype positivity, and colposcopic biopsy outcomes. Additionally, demographic factors such as age, parity, and menstrual status were not associated with high-grade cervical lesion development. Conclusion: The present study does not provide evidence that multiple HPV infections increase the risk of cervical dysplasia or cervical cancer. Larger, prospective studies are needed to better clarify the clinical impact of multiple HPV infections.
