Eda ÇOBAN, Elif KORKUT, Fazilet KARADEMİR, Rabia KARABIYIK, Nilüfer KALE İÇEN
Nöropsikiyatri Arşivi - 2026;63(1):316-320
Introduction: Large-artery atherosclerosis (LAA) is common in acute ischemic stroke, before determinants of whether LAA presents symptomatically or remains silent are unclear. We aimed to identify risk factors distinguishing symptomatic from asymptomatic LAA. Method: We retrospectively analyzed 411 consecutive patients with acute ischemic stroke and imaging-confirmed >= 50% stenosis/occlusion. Results: The mean age was 70.4 +/- 10.6 years. Hyperlipidemia was associated with symptomatic LAA (OR = 1.64; p = 0.023). AF was more frequent among asymptomatic LAA in those aged 61-99. TG/HDL was higher in symptomatic women and elevated across symptomatic patients aged 40-80. Conclusion: In elderly patients, hypertension; in men, hyperlipidemia; and in women and middle-to-older age groups, elevated TG/HDL are linked to symptomatic conversion of LAA. In the presence of AF, concomitant LAA often remains clinically silent.
