RUŞEN DÜNDARÖZ, ALİ SIZLAN, TUNCER DEĞİM, MEHMET YAŞAR, METİN DENLİ, TAHİR ÖZIŞIK
Kocatepe Tıp Dergisi - 2001;2(1):37-41
Status epilepticus can cause irreversible cerebral injury if it prolongs and it is essential to terminate seizure rapidly. Antiepileptic drugs should be introduced to the patients intravenously (IV), but it is almost impossible to achieve IV access during the seizure. However, intraosseous (IO) route can be accessible easily. Phenytoin was introduced to dogs by IV and IO routes. The levels of phenytoin in the blood were measured and the results were compared. The plasma profile of phenytoin was found to be in the therapeutic level when it was administered by IO route. It was concluded that the IO route can be an alternative route to IV route in the loading of phenytoin.
