SHAKUNTLA VERMA, MUNİSH AHUJA
Acta Pharmaceutica Sciencia - 2021;59(1):581-602
The objective of present study was to improve muco-adhesiveness of sesbania gum by thiol functionalization. Thiolated sesbania gum was synthesized by reacting sesbania gum with mercaptoacetic acid in the presence of catalytic amount of acids. The modified gum was characterized physic-chemically and for biocompatibility. Thiolated sesbania gum was tested as mucoadhesive polymer for pharmaceutical applications by formulating its composite beads in the sodium alginate using metformin as a model drug. Thiolation onto sesbania gum was confirmed by Fourier transform infrared spectroscopy and energy dispersive X-ray scanning electron micrographs. The degree of thiol substitution was found to be 1.72mmol/gm. The results of thrombogenic and haemolytic potential studies confirmed the biocompatibility of Thiolated sesbania gum. The comparative evaluation of composite beads of thiolated sesbania gum with sesbania gum and alginate alone beads revealed that thiolation of sesbania beads improves the bioadhesion property of sesbania gum.
