HİLAL KIZILTUNÇ ÖZMEN, FAZİLE NUR EKİNCİ AKDEMİR, AYHAN TANYELİ, SERKAN YILDIRIM, YASİN BAYIR, YILMAZ ŞAHİN, GİZEM ESER, AYŞENUR KAHRAMANLAR
Turkish Journal of Oncology - 2021;36(1):71-78
OBJECTIVE The goal of the present study was to evaluate the therapeutic efficacy of thymol in diminishing the damages to the liver and kidney tissues caused by the application of ionizing radiation. METHODS The experimental rats were randomized and grouped as follows: Group I (control), Group II (receiving ionizing radiation), and Group III (receiving thymol + ionizing radiation). Pathological tissue damage was assessed by immunohistochemical and biochemical analyses using chemical methods. RESULTS The level of plasma malondialdehyde (MDA) in both the tissues were significantly elevated in Group II compared to that in Group I (p<0.001 for both the tissues), but they were significantly lower in Group III than in Group II (p<0.01 for both the tissues). In addition, the plasma MDA level in both the tissues was increased in Group III than in Group I (p<0.05 for both the tissues). The level of superoxide dismutase (SOD) and glutathione (GSH) in the liver and kidney tissues were significant decreased in Group II than in Group I (p<0.001 for both the tissues and for both the parameters), while these parameters were increased in Group III relative to those in Group II (p<0.05 for both the tissues and for both the parameters). Moreover, the plasma SOD and GSH levels in both the tissues were decreased in Group III than in Group I (p<0.05 for both the tissues and for both the parameters). All these findings were supported by the pathological images of caspase-3 and 8-OHdG tests conducted in the study. CONCLUSION Our results demonstrated that the treatment of thymol in the rat models is useful in diminishing the liver and kidney damages caused by the application of ionizing radiation.
