MARWAH SAAD JOUDAH, ZAİNAB A ABBOOD, ZAİNAB HUSSEİN AJEEL, HADEEL SAEED HADI, HUSAM KAREEM HAMEED
Acta Pharmaceutica Sciencia - 2024;62(4):873-886
Wound infections are characterized by antibiotic-resistant bacteria, a growing issue. When these microbes infect a wound, it"s treated aggressively. A few therapeutic antibiotics make this therapy problematic. Mupirocin and other newly discovered methods show promise as bacterial wound-killing agents. This study includes three topical mupirocin-steroid therapies that were tested for their ability to treat antibiotic-resistant clinical isolates. Wounds may be treated using mupirocin-based liquid, cream, and dressing coating. The reduction in viable bacterial population after mupirocin exposure was used to compare the bactericidal efficiency of different mupirocin treatments. Results showed that each ingredient had the potential to reduce germ reproduction. The mupirocin-coated bandage was the most efficient strategy to kill antibiotic- resistant bacteria, whereas the liquid mupirocin was the least efficient. The mupirocin-coated steroid bandage swiftly killed the tested germs and showed promise against other bacterial strains. Mupirocin might be a therapeutic and prophylactic medication for wound colonization by organisms that hinder healing.
