Merve SOYHAN, Fusün GEDIZ
Acta Haematologica Oncologica Turcica - 2026;59(2):89-94
Aim: This study evaluated the toxicities associated with mobilization and conditioning regimens and examined the relationship of these toxicities to survival and transplant outcomes in patients with multiple myeloma (MM) and lymphoma undergoing high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation. Methods: We conducted a retrospective analysis of 58 patients treated at a single tertiary referral center in Türkiye. The median follow-up was 24 months. Toxicities were categorized by organ system and graded according to the Common Terminology Criteria for Adverse Events version 5.0. Results: For the entire cohort, overall survival (OS) was 89.5% at one month, 75.7% at twelve months, and 70.2% at the last follow-up. In MM, the three month treatment response was strongly associated with OS; OS was 94.1 percent for patients in remission and 35.7 percent for those with refractory disease (p<0.001). Across toxicity categories, no statistically significant associations were observed with OS or disease-free survival (DFS). In MM, mucositis and anemia did not show a statistically significant association with shorter DFS, yet the observed trend may be clinically relevant. Conclusion: In this single-center experience, regimen-related toxicities did not independently predict transplant outcomes or OS. Nevertheless, the direction and consistency of effects on mucositis and anemia in MM justify prospective confirmation. Multicenter studies with homogeneous patient populations are warranted to clarify the prognostic role of treatment-related toxicities and to refine supportive care strategies.
