Merve NENNİ, Tuğba TEHÇİ
Hacettepe University Journal of the Faculty of Pharmacy - 2025;45(4):338-344
Melasma, a condition causing uneven brown patches on the forehead, cheeks, and chin, is classified into epidermal, dermal, mixed, and indeterminate types. Treatment options include tranexamic acid (TXAA), which has been increasingly used recently. The 2,2?-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay is a widely accepted and often employed test for quantifying the overall antioxidant capacity of substances. The DPPH method was used to calculate the antioxidant scavenging percentages of TXAA and ascorbic acid (vitamin C). TXAA showed a DPPH radical scavenging activity of 60.77+/-0.34% at 50,000 ppm, while ascorbic acid showed a DPPH radical scavenging activity of 95.77+/-0.59% at 1000 ppm. Ascorbic acid is a known powerful antioxidant. After examining the results, it is clear that TXAA exhibits antioxidant activity, although it is less potent than the antioxidant effect of ascorbic acid.
