Arzuhan Çetindağ, Levent Hacısüleyman
European Journal of Multidisciplinary Health Sciences - 2026;11(1):0-0
Epilepsy is a neurological disorder affecting millions of individuals worldwide and remains a major focus of experimental research. The pentylenetetrazole (PTZ) -induced seizure model is widely used in preclinical epilepsy studies; however, its global resea rch landscape has not been systematically evaluated. In this study, a comprehensive bibliometric analysis of PTZ -related epilepsy publications was conducted to identify research trends, influential contributors, and evolving thematic areas. A total of 1,76 8 original articles published between January 2000 and October 2023 were retrieved from the Scopus database and analyzed using bibliometric tools, including Biblioshiny and VOSviewer, to assess publication output, citation patterns, authorship, institution al and national productivity, and conceptual structure. The results demonstrated a steady growth in PTZ -related publications over time, with China emerging as the leading contributor in terms of publication volume, while Poland showed a high degree of inte rnational collaboration. Among the retrieved publications, the most highly cited study focused on PTZ -induced behavioral and neural changes in zebrafish. Epilepsy and Behavior, Epilepsy Research, and Epilepsia were identified as the most productive journal s in this field. Keyword and thematic analyses revealed frequently studied topics such as oxidative stress, anticonvulsant activity, and neuroinflammation, along with emerging research interests including brain -derived neurotrophic factor and neuronal dama ge. This study represents the first bibliometric evaluation specifically focused on the PTZ -induced experimental epilepsy model and provides a comprehensive overview of the global research landscape. The findings may help researchers identify key contribut ors, recognize research gaps, and guide future experimental studies in epilepsy.
