ENSAR AYDEMİR, IZZET HAKKİ ARİKAN, ARDA BAYAR, RABİA GOKCEN UMURCA AYDEMİR, EBRU ASİCİOGLU, ARZU VELİOGLU, MEHMET KOC, ZUBEYDE SERHAN TUGLULAR, ISHAK CETİN OZENER
Annals of Medical Research - 2024;31(9):659-663
Aim: The Kidney Failure Risk Equation (KFRE) is a useful tool for predicting chronic kidney disease (CKD) progression to end-stage renal disease (ESRD). It has been validated in various populations. This study aimed to evaluate the prognostic significance of the KFRE model in a Turkish CKD cohort. Materials and Methods: In a prior retrospective study at a single center, the 4- variable KFRE model’s accuracy in predicting ESRD progression was assessed. Among 246 stage 3 or 4 CKD individuals, two-year risk predictions categorized participants into low-intermediate (<20%) and high (≥20%) risk groups. Results: The model showed a sensitivity of 48.9% (95% confidence interval [CI] 34.08 63.94) and a specificity of 89.45% (95% CI 84.3293.35) in predicting kidney failure progression in the Turkish population with stage 34 CKD. The area under the receiver operating characteristic curve was 0.69 (95% CI 0.600.79, p = 0.0001). Albuminuria, glomerular filtration rate, and reninaldosterone system blockage were independently associated with kidney failure progression according to the Cox regression analysis. Conclusion: The findings of this study have demonstrated that the KFRE model shows potential utility in predicting the progression of stage 34 chronic kidney disease (CKD) toward the critical stage of ESRD for the Turkish population.