İLKİN HAMİD ZADA MEHMET ÇAĞLAR ÇAKICI ÖZGÜR ARIKAN AHMET KELEŞ ASIF YILDIRIM
European Journal of Geriatrics and Gerontology - 2025;7(2):108-115
OBJECTIVE This study aimed to investigate the associations between the preoperative Prognostic Nutritional Index (PNI), Systemic Immune-Inflammation Index (SII), and short-term survival in octogenarian and non-agenarian patients who were admitted to the urology department. Materials and Methods We evaluated 136 octogenarian and non-agenarian patients who were admitted to the urology department. The patient-related data were collected, including demographic and comorbidities. Surgical treatment patterns and outcomes were assessed. Patients’ SII and PNI scores were calculated. PNI was calculated as total lymphocyte count (109/L) × 5 + albumin concentration (g/L). SII was calculated as neutrophil count (109/L) × platelet count (109/L)/lymphocyte count (109/L). The cut-off values of PNI and SII were determined through receiver operating characteristic analysis. Overall survival (OS) was estimated by Kaplan-Meier analysis. The log-rank test was used to compare differences between the groups. Univariate and multivariate COX regression analyses were performed to assess the predictive values of PNI and SII for OS. RESULTS The study population comprised 105 women (77.2%) and 31 men (22.8%), with a median age of 84 years (range, 80-97 years). The most common reason for hospitalization was hematuria, affecting 47 patients (34.6%). A total of 74 patients (54.4%) underwent surgical intervention. The optimal cut-off values for predicting OS were identified as 1243, 42.65, and 32.37 for SII, PNI, and SII/PNI, respectively. Kaplan-Meier analysis also revealed that low PNI was related to poorer OS in octogenarian and non-agenarian patients. CONCLUSION Preoperative PNI and SII, based on standard laboratory measurements, may be useful non-invasive, inexpensive, and simple tools for predicting short-term survival of octogenarian and non-agenarian patients admitted to the urology department.
