RAJESH KAZA, PRASANNA RAJUYALAVARTHI, NAGARAJU RAVOURU
Turkish Journal of Pharmaceutical Sciences - 2014;11(2):175-184
Recently researcher’s focused on valsartan fast dissolving films (FDF) and their development. Valsartan films were prepared by solvent casting method using different grades of HPMC (E5, E50 and K4M). Six formulations (FV1-FV6) of valsartan films were prepared and evaluated for their physical characteristics such as thickness, tensile strength, elongation, weight variation, folding endurance, drug content uniformity and surface pH and gave satisfactory results.The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. The formulations were subjected to disintegration, in vitro drug release and pharmacodynamic studies on spontaneous hypertensive rats (SHR). Formulation FV5 was found to be best formulations which contain HPMC E5 and valsartan solid dispersion with guar gum at weight ratio of 1:4 showed excellent film forming characteristics such as disintegration time of 57 sec and percentage drug release 95.95% within 10 minutes. The optimized film formulation (FV5) showed excellent stability over 45 days when stored at 40°C/60% relative humidity. The pharmacodynamic study of valsartan FDF in SHR proved the better therapeutic efficacy.
