SELİM İSBİR, UZAY GÖRMÜŞ, ATİKE TEKELİ, ARZU ERGEN, NİLÜFER YİĞİT, İLHAN YAYLIM ERALTAN, DERYA ÖZSAVCI, SİNAN ARSAN
Advances in Molecular Medicine - 2007;3(2):89-92
Vascular endothelial growth factor (VEGF) is a highly specific growth factor for vascular endothelial cells by both stimulating endothelial cell growth and enhancing vascular permeability. We investigated the effects of VEGF-460 T/C polymorphism on serum levels of VEGF in coronary artery disease. 26 first time elective coronary artery bypass grafting (CABG) patients with cardiopulmonary bypass (CPB) were enrolled in the study. VEGF -460T/C polymorphism analysis was performed by a PCR-RFLP method. VEGF levels were determined by enzyme immunoassay method. There was no significant relationship between VEGF levels before and after bypass surgery in T allele group. But there was a significant decrement of VEGF levels in C allele carriers after surgery.
