Radomir Gelevski, Gjorgji Jota, Blagica Krsteska, Vesna Jovanovska Manevska, Bojan Trenchikj, Natasha Jovanovska
Turkish Journal of Colorectal Disease - 2025;35(4):159-163
A 26-year-old man underwent appendectomy for acute phlegmonous appendicitis, and postoperative histopathology revealed a well-differentiated appendiceal neuroendocrine tumor (NET) (G1, 1.3 cm, Ki-67 <1%), confined to the subserosa without mesoappendiceal invasion or lymphovascular/perineural involvement. Surgical margins were clear, and the patient recovered uneventfully. According to guidelines, right hemicolectomy is selectively considered for 1-2 cm tumors with high-risk features. As none were present, appendectomy was deemed sufficient following a multidisciplinary team review. This case highlights the importance of thorough histopathological assessment and individualized management of incidentally detected appendiceal NETs within the 1-2 cm gray-zone category.
