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WHOLE GENOME SEQUENCING FOR DETECTING DRUG-RESISTANT MUTATIONS IN MYCOBACTERIUM TUBERCULOSIS IN ZIMBABWE

BEAUTY MAKAMURE, DAN WARD, TSİTSİ BANDASON, MARTHA CHİPİNDURO, COLLİNS TİMİRE, STEPHEN STEPHEN, FORGET MAKOGA, ISABEL MASHİTA, SHUNGU MUNYATİ, PASİPANODYA NZİRAMASANGA, JUNİOR MUTSVANGWA, JOHN Z METCALFE, JODY PHELAN, JUSTEN MANASA

Journal of Microbiology and Infectious Diseases - 2025;15(3):77-87

Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe

 

Background: Drug-resistant tuberculosis (DR-TB) is a major public health issue in Zimbabwe. Whole-genome sequencing (WGS) is recommended for studying drug-resistant mutations, lineages, prevalence, and transmission patterns. However, there are limited data on drug-resistant conferring mutations and WGS use in Zimbabwe.